Dari Kekebalan Kelompok ke Kekebalan Rapuh
Tinjauan Kebangkitan Campak
DOI:
https://doi.org/10.71456/jik.v5i1.2984Keywords:
Beban Ekonomi, Campak, Keraguan Vaksin, Kekebalan Kelompok, Ketahanan Sistem ImunisasiAbstract
Campak kembali meningkat di banyak negara setelah pandemi COVID-19. Indonesia juga mengalaminya. Sepanjang 2025, Indonesia mencatat 63.769 kasus yang diduga campak dan 69 kematian. Tinjauan ini bertujuan memahami mengapa kekebalan kelompok melemah, apa dampaknya, dan bagaimana sistem imunisasi merespons. Tinjauan ini memakai pendekatan tinjauan naratif. Sumbernya adalah 33 artikel jurnal terindeks Scopus yang terbit pada 2024–2026. Temuan disintesis secara tematik dengan dua kerangka, yaitu model 5C tentang keraguan vaksin dan kerangka ketahanan sistem kesehatan. Hasilnya menunjukkan dua jalur pemicu. Jalur pertama berasal dari masyarakat, terutama kekhawatiran soal keamanan dan kehalalan vaksin serta hambatan akses. Jalur kedua berasal dari sistem imunisasi yang terguncang pandemi, konflik, dan lemahnya pencatatan. Kedua jalur bermuara pada kesenjangan kekebalan yang terkumpul diam-diam, termasuk pada remaja dan dewasa muda. Biaya wabah naik lebih cepat daripada penurunan cakupan vaksin. Biaya per kasus berkisar dari sekitar 3 ribu hingga lebih dari 100 ribu dolar Amerika Serikat. Di Indonesia, pemicunya berbeda antarwilayah. Di sebagian wilayah, hambatan akses lebih menonjol. Di wilayah lain, keyakinan agama lebih menonjol. Tinjauan ini mengusulkan kerangka konseptual terpadu dengan lima proposisi yang dapat diuji. Implikasinya, strategi imunisasi perlu dibedakan menurut jenis hambatan di tiap wilayah.
References
Azhary, A., Hajhamed, N. M., Ali, E. T. O., Muvunyi, C. M., & Siddig, E. E. (2025). Resurgent multistate measles outbreak in Sudan amidst conflict: Urgent need for vaccination and international support. International Journal of Infectious Diseases, 160. https://doi.org/10.1016/j.ijid.2025.108066
Baethge, C., Goldbeck-Wood, S., & Mertens, S. (2019). SANRA—a scale for the quality assessment of narrative review articles. Research Integrity and Peer Review, 4. https://doi.org/10.1186/s41073-019-0064-8
Betsch, C., Schmid, P., Heinemeier, D., Korn, L., Holtmann, C., & Böhm, R. (2018). Beyond confidence: Development of a measure assessing the 5C psychological antecedents of vaccination. PLOS ONE, 13(12). https://doi.org/10.1371/journal.pone.0208601
Branda, F., Giovanetti, M., Petrosillo, N., Ahmed, M. M., Perra, M., Sanna, D., Ceccarelli, G., Ciccozzi, M., Bucci, E., & Scarpa, F. (2025). Measles and public health: An integrative approach. Biology Direct, 20. https://doi.org/10.1186/s13062-025-00693-0
Burgess, C., Lisul, B., Pawaskar, M., Petigara, T., Murtagh, J., Kanazir, M., Loncarevic, G., & Carias, C. (2024). Impact of the COVID-19 pandemic on measles vaccination coverage and estimated catch-up efforts for Serbia. The Pediatric Infectious Disease Journal, 43(10), 1011–1017. https://doi.org/10.1097/INF.0000000000004487
Chukwu, C. W., Herdicho, F. F., Rois, M. A., & Fatmawati. (2026). Forecasting and optimal control model to assess the potential role of vaccine hesitancy and supportive care in East Java measles outbreak. Computers in Biology and Medicine, 210. https://doi.org/10.1016/j.compbiomed.2026.111707
Colombo-Mendoza, L. O., Villalobos-Espinosa, J. del C., & Beltrán-Naturi, E. (2026). Deterioration of immunization resilience: A Bayesian machine learning assessment of the 2025–2026 measles outbreak in Mexico. International Journal of Infectious Diseases, 167. https://doi.org/10.1016/j.ijid.2026.108666
Costumato, L. (2021). Collaboration among public organizations: a systematic literature review on determinants of interinstitutional performance. International Journal of Public Sector Management, 34(3). https://doi.org/10.1108/IJPSM-03-2020-0069
Dalisay, S. N., Landicho, M., Lota, M. M., Fujimori, Y., Acacio-Claro, P. J., Roxas, E., Abeleda, A., Rosuello, J. Z., Dato, M., Vogt, F., Danchin, M., Belizario, V., & Kaufman, J. (2025). Behavioural and social drivers of routine childhood immunization in selected low coverage areas in the Philippines. Global Health Research and Policy, 10. https://doi.org/10.1186/s41256-025-00447-5
Daud, M. R. H. M., Yaacob, N. A., Arifin, W. N., Sani, J. A. M., & Ibadullah, W. A. H. W. (2024). Individual and contextual factors associated with measles infection in Malaysia: A multilevel analysis. Osong Public Health and Research Perspectives, 15(5), 429–439. https://doi.org/10.24171/j.phrp.2024.0156
de Soárez, P. C., Rozman, L. M., Fonseca, T. S., Borsari, P. R., Percio, J., Barrera, L. S. G., & Sartori, A. M. C. (2024). Economic burden of measles outbreaks: A cost-of-illness study in a middle-income country in the post-elimination era. Revista Panamericana de Salud Pública, 48. https://doi.org/10.26633/RPSP.2024.103
Hagan, J., Dashpagma, O., Vichit, O., Chham, S., Demberelsuren, S., Grabovac, V., Hossain, S., Iijima, M., Lee, C.-W., Purevdagva, A., Mariano, K., Evans, R., Zhang, Y., & Takashima, Y. (2024). Challenges for sustaining measles elimination: Post-verification large-scale import-related measles outbreaks in Mongolia and Cambodia, resulting in the loss of measles elimination status. Vaccines, 12(7). https://doi.org/10.3390/vaccines12070821
Hariyanto, T. I. (2026). Measles resurgence in Indonesia: The intersection of immunity gaps, subnational heterogeneity, and vaccine confidence. Vaccine, 91. https://doi.org/10.1016/j.vaccine.2026.129085
Hermawan, A., Irawan, I. R., Widiyanti, M., Rosnani, R., & Arifin, H. (2025). Association of socio-demographic factors with measles vaccination coverage among Indonesian children aged 12–23 months: A nationwide study. The Turkish Journal of Pediatrics, 67(3), 304–316. https://doi.org/10.24953/turkjpediatr.2025.5886
Hijano, D. R., Orenstein, W. A., & Oliveira, C. R. (2025). Measles resurgence and the fragility of herd immunity: Implications for pediatric infectious disease practice. Journal of the Pediatric Infectious Diseases Society, 14(11). https://doi.org/10.1093/jpids/piaf094
Huits, R., Buonfrate, D., O’Laughlin, K., Hamer, D. H., Libman, M., Emetulu, H., Larsen, C. S., Wejse, C., Kuhn, S., Chen, L., Papavarnavas, N., Parker, S., Epelboin, L., Djossou, F., Perret, C., Weitzel, T., Chappuis, F., Eperon, G., Perez-Molina, J. A., & Matteelli, A. (2025). Measles importations by international travelers, GeoSentinel 2019–2025. Travel Medicine and Infectious Disease, 67. https://doi.org/10.1016/j.tmaid.2025.102885
Kementerian Kesehatan Republik Indonesia (2025a). Kematian 20 anak jadi ancaman serius: Pemerintah dorong imunisasi massal campak. https://kemkes.go.id/id/kematian-20-anak-jadi-ancaman-serius-pemerintah-dorong-imunisasi-massal-campak
Kementerian Kesehatan Republik Indonesia (2025b). KLB campak meningkat, Kemenkes ingatkan pentingnya imunisasi lengkap. https://www.kemkes.go.id/id/klb-campak-meningkat-kemenkes-ingatkan-pentingnya-imunisasi-lengkap
Kementerian Kesehatan Republik Indonesia(2026). Kemenkes waspadai dinamika campak nasional dan global. https://www.kemkes.go.id/id/kemenkes-waspadai-dinamika-campak-nasional-dan-global
World Health Organization Indonesia (2026). Sumenep berhasil mengakhiri KLB campak. https://www.who.int/indonesia/id/news/detail/09-02-2026-sumenep-successfully-ended-measles-outbreak
Khanal, S., Bura, V., Sangal, L., Sethi, R., Dhongde, D., & Bahl, S. K. (2024). Progress towards measles and rubella elimination in the South-East Asia Region—2013–2023. Vaccines, 12(10). https://doi.org/10.3390/vaccines12101094
Kim, D. S., Son, T. J., Kim, H.-J., Park, C., Kim, S., Son, J., Choi, E.-J., La, B., Kim, M. H., Kim, Y., Lim, M.-A., Park, S. H., Kang, H. J., & Park, J.-H. (2025). Measles outbreak investigation at a university dormitory in the Republic of Korea, 2024. Journal of Korean Medical Science, 40(41). https://doi.org/10.3346/jkms.2025.40.e261
Kruk, M. E., Myers, M., Varpilah, S. T., & Dahn, B. T. (2015). What is a resilient health system? Lessons from Ebola. The Lancet, 385(9980), 1910–1912. https://doi.org/10.1016/S0140-6736(15)60755-3
Lorenzo, J. C., Islam, M. I., & Mathieu, E. (2026). Exploring socio-economic inequalities in measles immunisation in Lao People’s Democratic Republic, Thailand, and Viet Nam. Vaccine, 80. https://doi.org/10.1016/j.vaccine.2026.128507
Mattingly II, T. J. (2025). Penny wise, pound foolish: The cost of reduced support for measles prevention. Vaccine, 65. https://doi.org/10.1016/j.vaccine.2025.127830
Mohammed, A. G., Nukpezah, R. N., Mwin, P. K., Abdul-Manan, S., Baiden-Laryea, E., & Kenu, E. (2025). Coverage and predictors of full measles-rubella immunization among children aged 24–59 months in Northern Ghana: A post measles outbreak assessment. BMC Public Health, 25. https://doi.org/10.1186/s12889-025-22940-9
Murphy, A. A., Indah, R., Yufika, A., Ichsan, I., Liansyah, T. M., Harapan, H., Birchok, D., Pogue, J. M., Khairadini, F., & Wagner, A. L. (2025). Understanding the influence of religious and safety concerns on childhood measles and pertussis vaccination: A study conducted in Aceh, Indonesia, 2022. BMC Infectious Diseases, 25. https://doi.org/10.1186/s12879-025-11448-7
Mwale, M., Masumbu, P., Chipimo, P. J., Sakubita, P., Phiri, A., Matanda, K., Mwangilwa, K., Carcelen, A., Mutembo, S., Masaninga, F., Sakala, J., & Lugala, P. C. (2025). Bridging immunization gaps: Lessons from Zambia’s 2024 measles–rubella supplementary immunisation activity. Frontiers in Public Health, 13. https://doi.org/10.3389/fpubh.2025.1625514
Nampota-Nkomba, N., Keita, A. M., Juma, J., Sidibe, D., Kourouma, N., Sissoko, S., Haidara, F. C., Traore, C. T., Traore, C. B., Traore, A., Gaume, B., Sow, S. O., Kotloff, K. L., & Tapia, M. D. (2024). An upsurge of measles cases in Mali—A consequence of pandemic-associated disruption in routine immunization. Open Forum Infectious Diseases, 11(4). https://doi.org/10.1093/ofid/ofae154
Ong, T., Thuy, C. T., Tam, N. H., Nga, L. H., Uyen, N. T. V, Lan, T. T. T., Tran, A., Diem, L. T. K., Khang, H. P., Dung, D. T. X., Chuong, L. N., Tam, N. H. T., Giang, V. C., Cam, T. T. B., Anh, H. T. N., Thu, P. T. M., Man, D. N. H., Dung, N. T., Tung, N. L. N., … Van Tan, L. (2025). Detection of immunity gap before measles outbreak, Ho Chi Minh City, Vietnam, 2024. Emerging Infectious Diseases, 31(10), 2059–2062. https://doi.org/10.3201/eid3110.250234
World Health Organization (2023). Disease outbreak news: Measles – Indonesia. https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON462
Pike, J., Holzinger, N., Xiao, H. T., Stanislawski, E., Leung, J., Romero, A., & Smelser, C. (2026). Economic impact of the 2025 New Mexico measles outbreak: Highlighting the cost of efforts to prevent future outbreaks. Annals of Internal Medicine. https://doi.org/10.7326/ANNALS-26-00718
Rahayuningsih, N., Sinuraya, R. K., Fatinah, Y., Diantini, A., & Suwantika, A. A. (2024). Impact of COVID-19 pandemic on routine childhood immunization programs in Indonesia: Taking rural and urban area into account. Patient Preference and Adherence, 18, 667–675. https://doi.org/10.2147/PPA.S448901
Randell, M., Sheel, M., Dynes, M., Li, M., Danchin, M., Oktarinda, Sukesmi, F., Saraswati, L. D., Tinessia, A., Jenkins, K., Dewi, L. A., Saman, S., Yosephine, P., Leask, J., & Wahyono, T. Y. M. (2024). Influence of the COVID-19 pandemic on caregiver beliefs and experiences of routine childhood immunisation in Indonesia. Vaccine, 42(4), 812–818. https://doi.org/10.1016/j.vaccine.2024.01.013
Romadhon, D. I. (2026). “It was tidak cocok (incompatible)”: Incompatibility, decoloniality, and vaccine hesitancy in Banda Aceh, Indonesia. Medical Anthropology Quarterly, 40(2). https://doi.org/10.1111/maq.70024
Sayem, A. S. M., Musuka, G., Atuhebwe, P. L., Dadari, I., & Siddique, A. R. (2025). Childhood vaccination catch-up and recovery plans for mitigating immunity gap post the COVID-19 pandemic: A case study of selected African countries. Vaccine, 61. https://doi.org/10.1016/j.vaccine.2025.127328
Sukhera, J. (2022a). Narrative reviews: Flexible, rigorous, and practical. Journal of Graduate Medical Education, 14(4), 414–417. https://doi.org/10.4300/JGME-D-22-00480.1
Sukhera, J. (2022b). Narrative reviews in medical education: Key steps for researchers. Journal of Graduate Medical Education, 14(4), 418–419. https://doi.org/10.4300/JGME-D-22-00481.1
Tran, D. M., Ong, T., Cao, T. V, Pham, Q. T., Do, H., Phan, P. H., Choisy, M., & Pham, N. T. H. (2024). Hospital-acquired infections and unvaccinated children due to chronic diseases: An investigation of the 2017–2019 measles outbreak in the northern region of Vietnam. BMC Infectious Diseases, 24. https://doi.org/10.1186/s12879-024-09816-w
Ua, K., Hendrati, L. Y., Son, K. L., Sari, S. S. N., Astutik, E., & Sigunawan. (2025). Investigation of a measles outbreak in Brondong subdistrict, Lamongan district, Indonesia, 2023. Western Pacific Surveillance and Response Journal, 16(4), 43–49. https://doi.org/10.5365/wpsar.2025.16.1145
Wanlapakorn, N., Vichaiwattana, P., Thongmee, T., Chansaenroj, J., & Poovorawan, Y. (2025). Age-specific seroprevalence of measles, mumps, and rubella IgG across all age groups in Chonburi Province, Thailand after the coronavirus disease 2019 pandemic. The American Journal of Tropical Medicine and Hygiene, 112(6), 1385–1390. https://doi.org/10.4269/ajtmh.25-0005
Wells, C. R., Pandey, A., Ye, Y., Bawden, C., Giglio, R., Wong, C., Wang, V., Cipriano, C., Ayaz, L., Röst, G., Moghadas, S. M., Fitzpatrick, M. C., Singer, B. H., & Galvani, A. P. (2026). The health and economic repercussions of declining MMR coverage in the United States. Proceedings of the National Academy of Sciences of the United States of America, 123(17). https://doi.org/10.1073/pnas.2605971123
Xie, K., Marathe, A., Thakur, M., Chen, J., Deng, X., & Vullikanti, A. (2025). A health and economic evaluation of the spatial spillover effect from measles resurgence. Scientific Reports, 15. https://doi.org/10.1038/s41598-025-21097-0
Yitbarek, K., Mahimbo, A., Bobo, F. T., Woldie, M., Sheel, M., Frawley, J., & Hayen, A. (2025). Impact of measles vaccination strategies on vaccination rates in low-income and middle-income countries: A systematic review and meta-analysis. BMJ Global Health, 10(2). https://doi.org/10.1136/bmjgh-2024-016647
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Copyright (c) 2026 Asep Kuswandi, Mariya Ulfah, Titi Nurhayati, Syahrial Shaddiq, Syamsul Rizal Sinulingga, & Muhammad Ihsan

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